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A “Leap” toward Humanity’s Destruction

Published: June 25, 2021 | Print Friendly and PDF
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The world’s richest medical research foundation, the Wellcome Trust, has teamed up with a pair of former DARPA directors who built Silicon Valley’s skunkworks to usher in an age of nightmarish surveillance, including for babies as young as three months old. Their agenda can only advance if we allow it.

A UK nonprofit with ties to global corruption throughout the COVID-19 crisis as well as historical and current ties to the UK eugenics movement launched a global health-focused DARPA equivalent last year. The move went largely unnoticed by both mainstream and independent media.

The Wellcome Trust, which has arguably been second only to Bill Gates in its ability to influence events during the COVID-19 crisis and vaccination campaign, launched its own global equivalent of the Pentagon’s secretive research agency last year, officially to combat the “most pressing health challenges of our time.” Though first conceived of in 2018, this particular Wellcome Trust initiative was spun off from the Trust last May with $300 million in initial funding. It quickly attracted two former DARPA executives, who had previously served in the upper echelons of Silicon Valley, to manage and plan its portfolio of projects. 

This global health DARPA, known as Wellcome Leap, seeks to achieve “breakthrough scientific and technological solutions” by or before 2030, with a focus on “complex global health challenges.” The Wellcome Trust is open about how Wellcome Leap will apply the approaches of Silicon Valley and venture capital firms to the health and life science sector. Unsurprisingly, their three current programs are poised to develop incredibly invasive tech-focused, and in some cases overtly transhumanist, medical technologies, including a program exclusively focused on using artificial intelligence (AI), mobile sensors, and wearable brain-mapping tech for children three years old and younger. 

This Unlimited Hangout investigation explores not only the four current programs of Wellcome Leap but also the people behind it. The resulting picture is of an incredibly sinister project that poses not only a great threat to current society but to the future of humanity itself. An upcoming Unlimited Hangout investigation will examine the history of the Wellcome Trust along with its role in recent and current events.

Leap’s Leadership: Merging Man and Machine for the Military and Silicon Valley

Regina Dugan’s Keynote at Facebook F8 2017. Source: YouTube

 

The ambitions of the Wellcome Leap are made clear by the woman chosen to lead it, former director of the Pentagon’s DARPA, Regina Dugan. Dugan began her career at DARPA in 1996; she led a counterterrorism task force in 1999 before leaving DARPA about a year later. After departing DARPA, she cofounded her own venture capital firm, Dugan Ventures, and then became special adviser to the US Army’s vice chief of staff from 2001 to 2003, which coincided with the invasions of Afghanistan and Iraq. In 2005, she created a defense-focused tech firm called RedXDefense, which contracts with the military and specifically for DARPA.

In 2009, under the Obama administration, Dugan was appointed director of DARPA by Defense Secretary Robert Gates. Much was made over her being the first female director of the agency, but she is best remembered at the agency for her so-called “Special Forces” approach to innovation. During her tenure, she created DARPA’s now defunct Transformational Convergence Technology Office, which focused on social networks, synthetic biology, and machine intelligence. Many of the themes previously managed by that office are now overseen by DARPA’s Biological Technologies Office, which was created in 2014 and focuses on everything “from programmable microbes to human-machine symbiosis.” The Biological Technologies Office, like Wellcome Leap, pursues a mix of “health-focused” biotechnology programs and transhumanist endeavors.

Right before leaving the top role at DARPA, Dugan greenlighted the agency’s initial investments in mRNA vaccine technology, which led to DARPA’s investments in Pfizer and Moderna shortly thereafter. The DARPA scientist who lobbied Dugan to back the program, Dan Wattendorf, now works as the director of Innovative Technology Solutions at the Bill & Melinda Gates Foundation.

While Dugan’s efforts at DARPA are remembered fondly by those in the national-security state, and also by those in Silicon Valley, Dugan was investigated for conflicts of interest during her time as DARPA’s director, as her firm RedXDefense acquired millions in Department of Defense contracts during her tenure. Though she had recused herself from any formal role at the company while leading DARPA, she continued to hold a significant financial stake in the company, and a military investigation later found she had violated ethics rules to a significant degree.

Instead of being held accountable in any way, Dugan went on to become a top executive at Google, where she was brought on to manage Google’s Advanced Technology and Products Group (ATAP), which it had spun out of Motorola Mobility after Google’s acquisition of that company in 2012. Google’s ATAP was modeled after DARPA and employed other ex-DARPA officials besides Dugan. 

At Google, Dugan oversaw several projects, including what is now the basis of Google’s “augmented reality” business, then known as Project Tango, as well as “smart” clothing in which multitouch sensors were woven into textiles. Another project that Dugan led involved the use of a “digital tattoo” to unlock smartphones. Perhaps most controversially, Dugan was also behind the creation of a “digital authentication pill.” According to Dugan, when the pill is swallowed, “your entire body becomes your authentication token.” Dugan framed the pill and many of her other efforts at Google as working to fix “the mechanical mismatch between humans and electronics” by producing technology that merges the human body with machines to varying degrees. While serving in this capacity at Google, Dugan chaired a panel at the 2013 Clinton Global Initiative called “Game-Changers in Technology” and attended the 2015 Bilderberg meeting where AI was a main topic of discussion.

In 2016, Dugan left Google for Facebook where she was chosen to be the first head of Facebook’s own DARPA-equivalent research agency, then known as Building 8. DARPA’s ties to the origins of Facebook were discussed in a recent Unlimited Hangout report. Under Dugan, Building 8 invested heavily in brain-machine interface technology, which has since produced the company’s “neural wearable” wristbands that claim to be able to anticipate movements of the hand and fingers from brain signals alone. Facebook showcased prototypes of the project earlier this year. 

Dugan left Facebook just eighteen months after joining Building 8, announcing her plans “to focus on building and leading a new endeavor,” which was apparently a reference to Wellcome Leap. Dugan later said it was as if she had been training for her role at Wellcome Leap ever since entering the workforce, framing it as the pinnacle of her career. When asked in an interview earlier this year who the clients of Wellcome Leap are, Dugan gave a long-winded answer but essentially responded that the project serves the biotech and pharmaceutical industries, international organizations such as the UN, and public-private partnerships. 

In addition to her role at Wellcome, Dugan is also a member of the Council on Foreign Relations-sponsored taskforce on US Technology and Innovation policy, which was formed in 2019. Other members include LinkedIn’s Reid Hoffman, McKinsey Institute Global Chairman James Manyika, former head of Google Eric Schmidt and President Biden’s controversial top science adviser Eric Lander.

The other executive at Wellcome Leap, chief operating officer Ken Gabriel, has a background closely tied to Dugan’s. Gabriel, like Dugan, is a former program manager at DARPA, where he led the agency’s microelectromechanical systems (MEMS) research from 1992 to 1996. He served as deputy director of DARPA from 1995 to 1996 and became director of the Electronics Technology Office from 1996 to 1997, where he was reportedly responsible for about half of all federal electronics-technology investments. At DARPA, Gabriel worked closely with the FBI and the CIA.

Ken Gabriel – COO of Wellcome Leap. Source: Wellcome Leap

Gabriel left DARPA for Carnegie Mellon University, where he was in charge of the Office for Security Technologies in the aftermath of September 11, 2001. That office was created after 9/11 specifically to help meet the national-security needs of the federal government, according to Carnegie Mellon’s announcement of the program. Around that same time, Gabriel became regarded as “the architect of the MEMS industry” due to his past work at DARPA and his founding of the MEMS-focused semiconductor company Akustica in 2002. He served as Akustica’s chairman and chief technology officer until 2009, at which time he returned to work at DARPA where he served as the agency’s deputy director, working directly under Regina Dugan.

In 2012, Gabriel followed Dugan to Google’s Advanced Technology and Products Group, which he was actually responsible for creating. According to Gabriel, Google cofounders Larry Page and Sergey Brin tasked Gabriel with creating “a private sector ground-up model of DARPA” out of Motorola Mobility. Regina Dugan was placed in charge, and Gabriel again served as her deputy. In 2013, Dugan and Gabriel co-wrote a piece for the Harvard Business Review about how DARPA’s “Special Forces” innovation approach could revolutionize both the public and private sectors if more widely applied. Gabriel left Google in 2014, well before Dugan, to serve as the president and CEO of Charles Stark Draper Laboratories, better known as Draper Labs, which develops “innovative technology solutions” for the national-security community, with a focus on biomedical systems, energy, and space technology. Gabriel held that position until he abruptly resigned in 2020 to co-lead Wellcome Leap with Dugan. 

In addition to his role at Wellcome, Gabriel is also a World Economic Forum “technology pioneer” and on the board of directors of Galvani Bioelectronics, a joint venture of GlaxoSmithKline, which is intimately linked to the Wellcome Trust, and the Google subsidiary Verily. Galvani focuses on the development of “bioelectronic medicines” that involve “implant-based modulation of neural signals” in an overt push by the pharmaceutical industry and Silicon Valley to normalize transhumanist “medicines.” The longtime chairman of the board of Galvani, on which Gabriel serves, was Moncef Slaoui, who led the US COVID-19 vaccine development and distribution program Operation Warp Speed. Slaoui was relieved of his position at Galvani this past March over well-substantiated claims of sexual harassment.

Jeremy Farrar, Pandemic Narrative Manager

While Dugan and Gabriel ostensibly lead the outfit, Wellcome Leap is the brainchild of Jeremy Farrar and Mike Ferguson, who serve as its directors. Farrar is the director of the Wellcome Trust itself, and Ferguson is deputy chair of the Trust’s board of governors. Farrar has been director of the Wellcome Trust since 2013 and has been actively involved in critical decision making at the highest level globally since the beginning of the COVID crisis. He is also an agenda contributor to the World Economic Forum and cochaired the WEF’s Africa meeting in 2019. 

Farrar’s Wellcome Trust is also a WEF strategic partner and cofounded the COVID Action Platform with the WEF. Farrar was more recently behind the creation of Wellcome’s COVID-Zero initiative, which is also tied to the WEF. Farrar has framed that initiative as “an opportunity for companies to advance the science which will eventually reduce business disruption.” Thus far it has convinced titans of finance, including Mastercard and Citadel, to invest millions in research and development at organizations favored by the Wellcome Trust.

Wellcome Trust Director Jeremy Farrar with NTI Co-Chairman Sam Nunn, who led the 2001 Dark Winter exercise.
Source: NTI.com

Some of Wellcome’s controversial medical-research projects in Africa, as well as its ties to the UK eugenics movement, were explored in a December article published at Unlimited Hangout. That report also explores the intimate connections of Wellcome to the Oxford-AstraZeneca COVID-19 vaccine, the use of which has now been restricted or banned in several countries. As mentioned in the introduction, the Wellcome Trust itself is the subject of an upcoming Unlimited Hangout investigation (Part 2).

Jeremy Farrar, who was born in Singapore in 1961, had previously been director of the Oxford University Clinical Research Unit in Ho Chi Minh City, beginning in 1998. During that time, he authored numerous epidemiological research papers. He claimed in a 2014 Financial Times article that his decision to move to Vietnam was due to his disdain for conference halls full of white men. Southeast Asia was obviously a much less regulated environment for someone in the medical-research industry wishing to indulge in groundbreaking research. Although based in Vietnam, Farrar was sent by Oxford to various locations around the globe to study epidemics happening in real time. In 2009, when swine flu was wreaking havoc in Mexico, Farrar jumped on a plane to dive right into the action, something he also did for subsequent global outbreaks of EbolaMERS, and avian flu.

Over the past year, many questions have arisen regarding exactly how much power Farrar wields over global public health policy. Recently, the US president’s chief medical adviser, Anthony Fauci, was forced to release his emails and correspondence from March and April 2020 at the request of the Washington Post. The released emails reveal what appears to be a high-level conspiracy by some of the top medical authorities in the US to falsely claim that COVID-19 could only have been of zoonotic origin, despite indications to the contrary. The emails were heavily redacted as such emails usually are, supposedly to protect the information of the people involved, but the “(b)(6)” redactions also protect much of Jeremy Farrar’s input into these discussions. Chris Martenson, economic researcher and post-doctorate student of neurotoxicology and founder of Peak Prosperity, has had some insightful comments on the matter, including asking why such protection has been offered to Farrar given that he is the director of a “charitable trust.” Martenson went on to question why the Wellcome Trust was involved at all in these high-level discussions.

One Fauci email, dated February 25, 2020, and sent by Amelie Rioux of the WHO, stated that Jeremy Farrar’s official role at that time was “to act as the board’s focal point on the COVID-19 outbreak, to represent and advise the board on the science of the outbreak and the financing of the response.” Farrar had previously chaired the WHO’s Scientific Advisory Council. The emails also show the preparation, within a ten-day period, of the SARS-CoV-2 “‘origins” paper, which was entitled “The Proximal Origin of SARS-CoV-2” and was accepted for publication by Nature Medicine on March 17, 2020. The paper claimed that the SARS-CoV-2 virus could only have come from natural origins as opposed to gain-of-function research, a claim once held as gospel in the mainstream but which has come under considerable scrutiny in recent weeks. 

Shaping the presentation of an origin story for a virus of global significance is something Farrar has been involved with before. In 2004–5, it was reported that Farrar and his Vietnamese colleague Tran Tinh Hien, the vice director at the Hospital for Tropical Diseases, were the first to identify the re-emergence of the avian flu (H5N1) in humans. Farrar has recounted the origin story on many occasions, stating: “It was a little girl. She caught it from a pet duck that had died and she’d dug up and reburied. She survived.” According to Farrar, this experience prompted him to found a global network in conjunction with the World Health Organization to “improve local responses to disease outbreaks.” 

An article published by Rockefeller University Press’s Journal of Experimental Medicine in 2009 is dramatically titled, “Jeremy Farrar: When Disaster Strikes.” Farrar, when referring to the H5N1 origin story stated: “The WHO people—and this is not a criticism—decided it was unlikely that the child had SARS or avian influenza. They left, but Professor Hien stayed behind to talk with the child and her mum. The girl admitted that she had been quite sad in the previous days with the death of her pet duck. The girl and her brother had fought over burying the duck and, because of this argument, she had gone back, dug up the duck, and reburied it—probably so her brother wouldn’t know where it was buried. With that history, Professor Hien phoned me at home and said he was worried about the child. He took some swabs from the child’s nose and throat and brought them back to the hospital. That night the laboratory ran tests on the samples, and they were positive for Influenza A.”

With Farrar now having been revealed as an instrumental part of the team that crafted the official story regarding the origins of SARS-CoV-2, his previous assertions about the origin of past epidemics should be scrutinized. 

As the director of a “charitable trust,” Jeremy Farrar is almost completely unaccountable for his involvement in crafting controversial narratives related to the COVID crisis. He continues to be at the forefront of the global response to COVID, in part by launching the Wellcome Leap Fund for “unconventional projects, funded at scale” as an overt attempt to create a global and “charitable” version of DARPA. Indeed, Farrar, in conceiving Wellcome Leap, has positioned himself to be just as, if not more, instrumental in building the foundation for the post-COVID era as he was in building the foundation for the COVID crisis itself. This is significant as Wellcome Leap CEO Regina Dugan has labeled COVID-19 this generation’s “Sputnik moment” that will launch a new age of “health innovation,” much like the launching of Sputnik started a global technological “space age.” Wellcome Leap fully intends to lead the pack.

“Rulers” of the Gene-Sequencing Industry

In contrast to the overt DARPA, Silicon Valley, and Wellcome connections of the others, the chairman of the board of directors of Wellcome Leap, Jay Flatley, has a different background. Flatley is the long-time head of Illumina, a California-based gene-sequencing hardware and software giant that is believed to currently dominate the field of genomics. Though he stepped down from the board of Illumina in 2016, he has continued to serve as the executive chairman of its board of directors. Flatley was the first to be chosen for a leadership position at Wellcome Leap, and he was responsible for suggesting Regina Dugan for the organization’s chief executive officer, according to a recent interview given by Dugan. 

Illumina Campus. Source: Glassdoor

As a profile on Illumina in the business magazine Fast Company notes, Illumina “operates behind the scenes, selling hardware and services to companies and research institutions,” among them 23andMe. 23andMe’s CEO, Anne Wojcicki, the sister of YouTube CEO Susan Wojcicki and the wife of Google cofounder Sergey Brin, told Fast CompanyIt’s crazy. Illumina is like the ruler of this whole universe and no one knows that.” The report notes that 23andMe, like most companies that offer DNA sequencing and analysis to consumers, uses machines produced by Illumina. 

In 2016, Illumina launched an “aggressive” five-year plan to “bring genomics out of research labs and into doctors’ offices.” Given the current state of things, particularly the global push toward gene-focused vaccines and therapies, that plan, which concludes this year, could not have been any better timed. Illumina’s current CEO, Francis DeSouza, previously held key posts at Microsoft and Symantec. Also in 2016, Illumina’s executive teams forecast a future in which humans are gene tested from birth to grave for both health and commercial purposes.

Whereas most companies have struggled financially during the coronavirus pandemic, some have seen a massive increase in profits. Illumina has witnessed its share price double since the start of the COVID crisis. The company’s $1 billion plus in profits during the last tax year was obviously helped by the quick approval of the NovaSEQ 6000 machines, which can test a large number of COVID samples more quickly than other devices. An individual machine has a hefty price tag of almost $1 million, and thus they are mostly found at elite facilitiesprivate labs, and top-tier universities.

Jay Flatley, Executive Chairman, Illumina, speaking at World Economic Forum in Davos 2018. Source: WEF

In addition to his long-standing leadership role at Illumina, Jay Flatley is also a “digital member” of the World Economic Forum as well as the lead independent director of Zymergen, a WEF “tech pioneer” company that is “rethinking biology and reimagining the world.” Flatley, who has also attended several Davos meetings, has addressed the WEF on the “promise of precision [i.e., gene-specific] medicine.” At another WEF panel meeting, Flatley, alongside UK Health Secretary Matt Hancock, promoted the idea of making genomic sequencing of babies at birth the norm, claiming it had “the potential to shift the healthcare system from reactive to preventative.” Some at the panel called for the genomic sequencing of infants to eventually become mandatory.

Aside from Flatley as an individual, Illumina as a company is a WEF partner and plays a key role in its platform regarding the future of health care. A top Illumina executive also serves on the WEF’s Global Future Council on Biotechnology. 

A New HOPE

Wellcome Leap currently has four programs: Multi-Stage Psych, Delta Tissue, 1KD, and HOPE. HOPE was the first program to be announced by Wellcome Leap and stands for Human Organs, Physiology and Engineering. According to the full program description, HOPE aims “to leverage the power of bioengineering to advance stem cells, organoids, and whole organ systems and connections that recapitulate human physiology in vitro and restore vital functions in vivo.”

Source: Wellcome Leap, https://wellcomeleap.org/hope/

HOPE consists of two main program goals. First, it seeks to “bioengineer a multiorgan platform that recreates human immunological responses with sufficient fidelity to double the predictive value of a preclinical trial with respect to efficacy, toxicity and immunogenicity for therapeutic interventions.” In other words, this bioengineered platform mimicking human organs would be used to test the effects of pharmaceutical products, including vaccines, which could create a situation in which animal trials are replaced with trials on gene-edited and farmed organs. Though such an advance would certainly be helpful in the sense of reducing often unethical animal experimentation, trusting such a novel system to allow medical treatments to go straight to the human-testing phase would also require trusting the institutions developing that system and its funders. 

As it stands now, the Wellcome Trust has too many ties to corrupt actors in the pharmaceutical industry, having originally begun as the “philanthropic” arm of UK drug giant GlaxoSmithKline, for anyone to trust what they are producing without actual independent confirmation, given the histories of some of their partners in fudging both animal and human clinical trial data for vaccines and other products.

The second goal of HOPE is to open up the use of machine-human hybrid organs for transplantation into human beings. That goal focuses on restoring “organ functions using cultivated organs or biological/synthetic hybrid systems” with the later goal of bioengineering a fully transplantable human organ after several years. 

Later on in the program description, however, the interest in merging the synthetic and biological becomes clearer when it states: “The time is right to foster synergies between organoids, bioengineering and immunoengineering technologies, and advance the state-of-the-art of in vitro human biology . . . by building controllable, accessible and scalable systems.” The program description document also notes the interest of Wellcome in genetic-engineering approaches for the “enhancement of desired properties and insertion of traceable markers” and Wellcome’s ambition to reproduce the building blocks of the human immune system and human organ systems through technological means.

Transhumanist Toddlers?

The second program to be pursued by Wellcome Leap is called “The First 1000 Days: Promoting Healthy Brain Networks,” which is abbreviated as 1KD by the organization. It is arguably the most unsettling program because it seeks to use young children, specifically infants from three months to three-year-old toddlers, as its test subjects. The program is being overseen by Holly Baines, who previously served as strategy development lead for the Wellcome Trust before joining Wellcome Leap as the 1KD program leader. 

Source: Wellcome Leap, https://wellcomeleap.org/1kd/

1KD is focused on developing “objective, scalable ways to assess a child’s cognitive health” by monitoring the brain development and function of infants and toddlers, allowing practitioners to “risk-stratify children” and “predict responses to interventions” in developing brains. 

The program description document notes that, up to this point in history, “our primary window into the developing brain has been neuroimaging techniques and animal models, which can help identify quantitative biomarkers of [neural] network health and characterise network differences underlying behaviours.” It then states that advances in technology “are opening additional possibilities in young infants.”

The program description goes on to say that artificial neural networks, a form of AI, “have demonstrated the viability of modelling network pruning process and the acquisition of complex behaviours in much the same way as a developing brain,” while improvements in machine learning, another subset of AI, can now be used to extract “meaningful signals” from the brains of infants and young children. These algorithms can then be used to develop “interventions” for young children deemed by other algorithms to be in danger of having underdeveloped brain function. 

The document goes on to note the promise of “low-cost mobile sensors, wearables and home-based systems” in “providing a new opportunity to assess the influence and dependency of brain development on natural physical and social interactions.” In other words, this program seeks to use “continuous visual and audio recordings in the home” as well as wearable devices on children to collect millions upon millions of data points. Wellcome Leap describes these wearables as “relatively unobtrusive, scalable electronic badges that collect visual, auditory and motion data as well as interactive features (such as turn-taking, pacing and reaction times).” Elsewhere in the document there is a call to develop “wearable sensors that assess physiological measures predictive of brain health (e.g., electrodermal activity, respiratory rate, and heart rate) and wireless wearable EEG or eye-tracking technology” for use in infants and children three and under.

Like other Wellcome Leap programs, this technology is being developed with the intention of making it mainstream in medical science within the next five to ten years, meaning that this system—although framed as a way to monitor children’s brain functioning to improve cognitive outcomes—is a recipe for total surveillance of babies and very young children as well as a means for altering their brain functioning as algorithms and Leap’s programmers see fit. 

1DK has two main program goals. The first is to “develop a fully integrated model and quantitive measurement tools of network development in the first 1000 days [of life], sufficient to predict EF [executive function] formation before a child’s first birthday.” Such a model, the description reads, “should predict contributions of nutrition, the microbiome and the genome” on brain formation as well as the effects of “sensimotor and social interactions [or lack thereof] on network pruning processes” and EF outcomes. The second goal makes it clear that widespread adoption of such neurological-monitoring technologies in young children and infants is the endgame for 1DK. It states that the program plans to “create scalable methods for optimising promotion, prevention, screening and therapeutic interventions to improve EF by at least 20% in 80% of children before age 3.” 

True to the eugenicist ties of the Wellcome Trust (to be explored more in-depth in Part 2), Wellcome Leap’s 1DK notes that “of interest are improvements from underdeveloped EF to normative or from normative to well-developed EF across the population to deliver the broadest impact.” One of the goals of 1DK is thus not treating disease or addressing a “global health public challenge” but instead experimenting on the cognitive augmentation of children using means developed by AI algorithms and invasive surveillance-based technology.

Another unsettling aspect of the program is its plan to “develop an in vitro 3D brain assembloid that replicates the time formation” of a developing brain that is akin to the models developed by monitoring the brain development of infants and children. Later on, the program description calls this an “in-silico” model of a child’s brain, something of obvious interest to transhumanists who see such a development as a harbinger of the so-called singularity. Beyond that, it appears that this in-silico and thus synthetic model of the brain is planned to be used as the “model” to which infant and children brains are shaped by the “therapeutic interventions” mentioned elsewhere in the program description.

It should be clear how sinister it is that an organization that brings together the worst “mad scientist” impulses of both the NGO and military-research worlds is openly planning to conduct such experiments on the brains of babies and toddlers, viewing them as datasets and their brains as something to be “pruned” by machine “intelligence.” Allowing such a program to advance unimpeded without pushback from the public would mean permitting a dangerous agenda targeting society’s youngest and most vulnerable members to potentially advance to a point where it is difficult to stop.

A “Tissue Time Machine”

The third and second-most recent program to join the Wellcome Leap lineup is called Delta Tissue, abbreviated by the organization as ΔT. Delta Tissue aims to create a platform that monitors changes in human-tissue function and interactions in real time, ostensibly to “explain the status of a disease in each person and better predict how that disease would progress.” Referring to this platform as a “tissue time machine,” Wellcome Leap sees Delta Tissue as being able to predict the onset of disease before it occurs while also allowing for medical interventions that “are targeted to the individual.”

Source: Wellcome Leap, https://wellcomeleap.org/delta-tissue/

Well before the COVID era, precision medicine or medicine “targeted or tailored to the individual” has been a code phrase for treatments based on patients’ genetic data and/or for treatments that alter nucleic acid (e.g., DNA and RNA) function itself. For instance, the US government defines “precision medicine” as “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Similarly, a 2018 paper published in Technology notes that, in oncology, “precision and personalized medicine . . . fosters the development of specialized treatments for each specific subtype of cancer, based on the measurement and manipulation of key patient genetic and omic data (transcriptomics, metabolomics, proteomics, etc.).” 

Prior to COVID-19 and the vaccine roll outs, the mRNA vaccine technology used by the DARPA-funded companies Moderna and Pfizer were marketed as being precision medicine treatments and were largely referred to as “gene therapies” in media reports. They were also promoted heavily as a revolutionary method of treating cancer, making it unsurprising that the Delta Tissue program at Wellcome Leap would use a similar justification to develop a program that aims to offer tailored gene therapies to people before the onset of a disease. 

This Delta Tissue platform works to combine “the latest cell and tissue profiling technologies with recent advances in machine learning,” that is, AI. Given Wellcome Leap’s connections to the US military, it is worth noting that the Pentagon and Google, both former employers of Wellcome Leap CEO Regina Dugan and COO Ken Gabriel, have been working together since last September on using AI to predict disease in humans, first focusing on cancer before expanding to COVID-19 and every disease in between. The Delta Tissue program appears to have related ambitions, as its program description makes clear that the program ultimately aims to use its platform for a host of cancers and infectious diseases.

The ultimate goal of this Wellcome Leap program is “to eradicate the stubbornly challenging diseases that cause so much suffering around the world.” It plans to do this through AI algorithms, however, which are never 100 percent accurate in their predictive ability, and with gene-editing treatments, nearly all of which are novel and have not been well tested. That latter point is important given that one of the main methods for gene-editing in humans, CRISPR, has been found in numerous studies to cause considerable damage to the DNA, damage that is largely irreparable (see herehere and here). It seems plausible that a person placed on such a hi-tech medical treatment path will continue to need a never-ending series of gene-editing treatments and perhaps other invasive hi-tech treatments to mitigate and manage the effects of clumsy gene splicing.

Total Surveillance to Treat “Depression”

Wellcome Leap’s most recent program, launched just this week, is called “Multi-Channel Psych: Revealing Mechanisms of Anhedonia” and is officially focused on creating “complex, biological” treatments for depression. 

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